ESOMEPRAZOLE?

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Showjumpinganna

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Basically … has anyone used Gastrogard and Omeprazole injections without much improvement?

Have you then tried Esomeprazole with success?

Would like to add horse is on low sugar / starch feed. On full livery so routine is always the same. Every single horse in the yard that has scoped for ulcers has cleared within 60 days. My boys will not get any better!

We originally started at grade 4 and we are now grade 3, 5 months later……..

He was 5 stage vetted in May full x rays, has had full lameness work up done since and sound as a pound.

Please no vet questions, my vet is heavily involved and we are all trying to figure why they won’t clear.

Are there horses that just don’t respond to Omeprazole?
 
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Showjumpinganna said:
Basically … has anyone used Gastrogard and Omeprazole injections without much improvement?

Have you then tried Esomeprazole with success?

Would like to add horse is on low sugar / starch feed. On full livery so routine is always the same. Every single horse in the yard has cleared within 60 days. My boys will not get any better!

We originally started at grade 4 and we are now grade 3, 5 months later……..

He was 5 stage vetted in May full x rays, has had full lameness work up done since and sound as a pound.

Are there horses that just don’t respond to Omeprazole?
Click to expand...

Are you saying that every horse on your yard has had ulcers? Because that would suggest there is something very wrong with the environment. How much turnout does he get, how much forage, what is the grazing like? Hopefully I am reading this wrong but for every horse on the yard to have ulcers sounds incredibly concerning to me and I would be looking to move asap.
 
Showjumpinganna said:
Basically … has anyone used Gastrogard and Omeprazole injections without much improvement?

Have you then tried Esomeprazole with success?

Would like to add horse is on low sugar / starch feed. On full livery so routine is always the same. Every single horse in the yard has cleared within 60 days. My boys will not get any better!

We originally started at grade 4 and we are now grade 3, 5 months later……..

He was 5 stage vetted in May full x rays, has had full lameness work up done since and sound as a pound.

Are there horses that just don’t respond to Omeprazole?
Click to expand...
Have you figured out the initial cause of him developing ulcers? Have you made lifestyle changes to try and prevent a reoccurance?

Giving gastroguard and changing nothing is unlikely to work.
 
Miss_Millie said:
Are you saying that every horse on your yard has had ulcers? Because that would suggest there is something very wrong with the environment. How much turnout does he get, how much forage, what is the grazing like? Hopefully I am reading this wrong but for every horse on the yard to have ulcers sounds incredibly concerning to me and I would be looking to move asap.
Click to expand...
every single horse at the yard who has scoped for ulcers has cleared within 2 months, usually 28 days and then tapered off.

Did not mention every horse at the yard has ulcers.

Management has been reviewed, vet is heavily involved and we cannot work out why they will not clear.

My yard is run like clockwork, management does not need any more reviewing as it’s as good as it can be.

Would like to add this is not by any means my first rodeo with ulcers over the past q few years I have had many horses. Said horse was new to me end of May.

My question is asking if horses have been unresponsive to Omeprazole but responsive to Esomeprazole.
 
Showjumpinganna said:
My yard is run like clockwork, management does not need any more reviewing as it’s as good as it can be.

Would like to add this is not by any means my first rodeo with ulcers over the past q few years I have had many horses. Said horse was new to me end of May.

My question is asking if horses have been unresponsive to Omeprazole but responsive to Esomeprazole.
Click to expand...

With all due respect, 'run like clockwork' does not not mean that the management isn't impacting your horse negatively. Stress (lack of turnout) causes ulcers, inappropriate/not enough forage can cause ulcers, a range of lifestyle triggers can cause ulcers if there is no underlying pain causing them.

Omeprazole is a harsh drug, it can cause acidosis of the hind gut and hind gut dysbiosis. If your horse has not responded to it I would suggest that there is probably something wrong with the management.
 
You probably need to be looking at other drugs in combination with omeprazole eg. misoprostol or sucralfate, rather than changing to a drug which is extremely similar to the one you're already using. However it will totally depend on the type and location of the ulcers (are you dealing with ESGD or EGGD? The two need to be tackled differently), and this will be up to your vet to assess. It may be that they need to involve a medicine specialist. These refractory cases can be very tricky to get to the bottom of. Orthopaedic pain is often a root cause, and this might not be visible as an obvious lameness.
 
Some ulcers are very stubborn to clear, what type are they? Hind gut or foregut? Do you know exact location? There are several good facebook groups you might get more specific advice on:

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Grade 4 are tough to sort out, mine had grade 2/3 and they cleared up with a month of gastroguard alone. And change to diet etc of course. We did find eventually some pain in his SIJ so have medicated that and hopefully that will stop them returning.

He sounds happy in his routine, have you also changed his feed? Has he had a full lameness work up? Our vet did that at the same time as the scope (well the same visit, he stayed over!)
 
Esomeprazole is just more bio available omeprazole (it’s the sinister isomer I believe) so you can halve the dose and get the same results… so if at the same dose it is double dose iyswim …
 
Your question isn't as cut and dried as you think it is. Mine has responded better to esomeprazole than omeprazol. However, the 'routine' on full livery yards was more 'people' friendly than 'horse' friendly. My horse is now far far happier off full livery and being looked after by me. My horse gets 1:1 attention rather than just being a number and therefore I can't fully confirm if it is the esomeprazole that has helped, or change in routine.
I do find it odd that this yard that runs like clockwork has had numerous horses diagnosed with ulcers.
 
We’ve been on gastroguard, Omeprazole, mesoprostal, sucralfate and then esomeprazole but to be fair the ulcers have improved but the nodule stopping the stomach emptying has not (laser gastroscopy booked for next month).

To be honest I would seek advise from your vet.
 
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