Pemphigus - any experience?

Box_Of_Frogs

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Asking on behalf of a friend. 6 weeks ago they took pity on a terribly sick looking TB and bought him. Owners said he was "poor" because had recently been on long term box rest, possibly cross tied, not sure. Friends have been trying all the usual things to get weight and condition back on him but to their horror he has suffered an almost complete systems shut down. He has developed a very rare auto-immune condition called pemphigus. He has coronitis in all 4 feet, with pus oozing out continuously. Ergots and chestnuts oozing serum and blood. Skin flaking. All mucus membranes inflamed and raw. Symptoms of belly ache too. He's eating like mad but it all just comes squirting out the other end. He's put on the tiniest amount of condition in the 6 weeks but he's in a bad place, sometimes driven so mad by the coronitis that he lies down and chews his feet. This has given him awful sores around his mouth. He's been on antibx which help but the minute he's taken off them, he deteriorates again. He's only 6 love him. They've spoken to Prof Knottenbelt who has advised it is a very serious disease with a guarded-to-poor prognosis. He has said they need a peritoneal tap to be performed asap to look for free blood in the abdomen and some other diagnostic procedures that I can't remember. Of course, he wasn't insurable.

I know this is desperate and the friend - very experienced horse owner - knows that there may come a time when they need to call it a day. But if there is the tiniest hope of a recovery they want to offer it to this lovely chap. Has anyone had any experience of this awful disease, good or bad? If good, do you have any idea what it was that "turned the corner"? Thanks all.
 
We had a springer spaniel with this. Before it was diagnosed he was in a very poor state - lots of ulcers on all mucous membrance areas including his anus, hair loss,an acne like rash & the skin on his nose crusted over & peeled off. This was over 20 years ago & our Vet had never seen a case before. Once they worked out what it was he was treated with steroids & made a full recovery. He had flare ups every so often & we took him straight to the Vets for another course of steroids. He lived happily & otherwise healthily for another 10 years & died aged 14.
I guess the outlook for your friends horse depends on how long his immune system has been attacking his body & whether any permanent damage has been done.
 
Sounds like what a friend's horse suffered from last year. Last resort was a massive dose of steroids. Unfortunately, he had to be put to sleep.
 
As with hairycob my only experience of this was with a dog, my current lovely Rhodesian Ridgeback in fact. She had it severely as a puppy and was in a dreadful state, her face all swollen and could hardly see. We were days away from having her PTS but with steroids she made a full recovery and has been healthy ever since (she is now 7). Though we decided not to breed from her in case the hormonal changes triggered it again (she had it at puberty). Hope your fiend's horse recovers.
 
This sound similar to my youngster's problems - although the current thinking is that she has an allergy to some species of grass. She had all over urticaria, weeping serum, and eventually colicked needing surgery. During recovery she became very ill with what they thought was salmonella, but turned out to be - you guessed it - the allergy kicking in again.
To save her life, she was put on 1mg/kg bodyweight of Prednisolone, the plan being to proceed to 2mg if that didn't work, then dexamethasone as a last resort before PTS.
The 1mg worked - and she came home. I am now in the process of gradually reducing her Preds (now on 0.5mg) with a view to having her skin tested in the spring to identify the allergen/s and eliminate them from her diet/environment where possible. It is also possible that she can be 'immunised' against the allergen, or possibly have a gold salts injection to 'distract' her immune system.
If that fails, she will have to live on Preds or be PTS.
To be brutally honest, my horse has cost me 9K this year in vet bills, and if your friends are not yet attached to their horse, I'd suggest PTS might be the best thing.
S :D
 
One of my livery horses has pemphigus and we manage it through steroid treatment. It flares worse in the winter than the summer but we now seem to have got on top of the treatment. This horse happily competes and enjoys a "normal" life.
I'm sure there are some cases out there that may not have such a good out-turn, but I just wanted to let you know that it is OK to hope!
 
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