Previcox dosage - help!

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ropa

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Hi folks of the online support world! I wonder if you can all chip in and let me know what dose they feed their horses of previcox? My boy is pretty sore and so wondering how high other people have dosed thir horses as considering upping his dose. Not a lot of research into the toxicity levels though. Thankfully this drug is better on the tummy than bute so less or a risk with over dosing and ulcers but it would be super tohear some real life stories in previcox dosages and any effects

Many Thnaks!
 
Why would you use non-licensed Previcox in place of licensed products? Yes - Previcox may reduce risk of gastro-intestinal irritation in dogs - this is known due to product licensing but how do you know that the same applies to horses?
Speak to your vet about this!
 
Because it is exactly the same drug as an equine licensed version and is 10% of the price. Of course I have spoken to my vet - sigh. According to the vet toxicity studies have not been carried out hence me reaching out for real life studies.
 
Friends horse is on 1/4 tab a day. 15.3 chunky monkey, prescribed by the vet for arthritis. It is licensed for horses, so they must've done toxicity tests?
 
Thank you that is so useful. I see that it says that a horse has problems at 2.5x the dose. It would be really useful to know if many of the horses had a problematic this level or just a couple of them. Does anyone know how to find out the detail and data behind the study?
 
ropa said:
Because it is exactly the same drug as an equine licensed version and is 10% of the price. Of course I have spoken to my vet - sigh. According to the vet toxicity studies have not been carried out hence me reaching out for real life studies.
Click to expand...

Okay, sorry, I don't think I put my above point very clearly.

What I was alluding to, which doesn't answer your original question is -

- As far as I am aware, Firocoxib is only licensed for horses in the UK in injectable or paste form and should only be prescribed in these forms. I appreciate the cost difference but unfortunately that cannot be used as a reason to prescribe a non-licensed product when a licensed alternative is available.

- It would be impossible to advise on toxic levels or comment on the likely impact of any drug on the gastric (or duodenal) mucosa when that preparation of the drug has not been trialled or licensed for a species ie - how do you know what potential toxic levels or gastro-intestinal impact Previcox tablets may have in horses even though the active ingredient is the same as that in the paste & injectable preparation?

Hopefully that's a bit clearer?
 
Update! there have been a few studies carried out which my vet read to me. They weren't large number of horses in each study which means they are not as reliable as they could be. However, the long and short of it was that a dosage of 3.5 tablet for a 550kg horse, effected the horses with some signs of lesions in the mouth and gums which my vet said was indicative that there may have been something else going on inside like the guts leaking etc. My vet said that she wouldn't be giving anymore than 2.5 tablets a day based on the effects. I have tried to find the study but for some reason I can't - sorry!

Anyway, thank goodness for some reason my horse is a lot lot better! We have cut his tablets and simultaneously he is much more comfortable - go figure! We suspect that the arthritis was not the problem and in fact it was a tweak in the field and a soft tissue problem, which combined with the arthritis was making him very sore. The farrier and vet and all the support have been unbelievable. Thank you.
 
I'm not sure why you would want to deliberately overdose your horse? Any potential adverse events which may be present at "normal" levels are at significantly greater risk of occurring at higher doses, and may occur with greater intensity or severity.

While COX-2 inhibitors are generally less gstro-irritant than "traditional" NSAIDS there is still a risk of GI haemorrhage/perforation.

The recommended dosage for horses is 0.1mg/kg body weight. One syringe contains a total of 60mg (equivalent active ingredient), which is only 3g more than a single (dog) tablet.

Personally, if your horse isn't comfortable on the max recommended dose, you need to either a) change the medication or b) consider the quality of life for your horse.
 
Because I am trying to do my best for my horse and was desperately trying to find out answers for a relatively new drug in a market where there are few options and because my vet suggested it as an option to increase the dose. I take your point but would be grateful if you arent so accusatory and sharp with your response as I have been having a really hard time with a horse I have been considering having pts. Thankfully it seems we are out if the woods though. I wonder how many other people have given their horses more bute than recommended for example during an acute injury
 
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