Chinchilla
...
Posted recently about my girthy mare being scoped. She turned out not to have ulcers but prior to this being known I did lots of research on how to help horses with ulcers. There's plenty that can be done alongside conventional treatments so just dropping what I found here.
It's all meant to be done WITH Omeprazole treatment though, not instead of, and most of the studies were done in rodents as mice & rats genome is 95% identical to the human genome and other rodents (e.g. guinea pigs) have a very similar immune system. Plus they are cheaper and easier to keep than horses who are large, potentially dangerous, and expensive to keep in a lab setting.
Dosages were for my horse's estimated weight of 500kg. So adjust as necessary.
As always, polite correction re. the sciencey bits is welcomed.
Supplementing with Convolvulaceae family
Sweet potatoes - a member of the Convolvulaceae - has been found to have ulcer-reducing properties as they reduce the presence of free radicals and thereby reduce oxidative stress.
Equine dose is calculated off 200mg/kg dosage for rats: 200mg = 0.28 grams. 0.2 * 500 = 100
Motawi TK1, Hamed MA, Hashem RM, Shabana MH, Ahmed YR., January 2012, 'Protective and therapeutic effects of Argyreia speciosa against ethanol-induced gastric ulcer in rats.' Z Naturforsch C., volume 67, issue 1-2, pages 47 - 57.
Jaiswal SK1, Rao CV, Sharma B, Mishra P, Das S, Dubey MK., 1st September 2011, 'Gastroprotective effect of standardized leaf extract from Argyreia speciosa on experimental gastric ulcers in rats.' J Ethnopharmacol, Volume 137, issue 1, pages 141 - 4.
Awaad AS1, Al-Refaie A2, El-Meligy R3, Zain M4, Soliman H5, Marzoke MS6, El-Sayed N7., December 2016, 'Novel Compounds with new Anti-Ulcergenic Activity from Convolvulus pilosellifolius Using Bio-Guided Fractionation.' Phytother Res., volume 30, issue 12, pages 2060 - 64. DOI: 10.1002/ptr.5730.
Plaintain: (Ribwort and Broadleaf): 1.4 kg/day (pm)
These common members of the Plantaginacae family promote mucous production, thereby reducing acidity via dilution and neutralisation. They also contain compounds which promote tissue growth and repair - accelerating the healing process - and reduce oxidative stress, which is soothing.
Equine dosage was calculated off a rodent dose of 2.8mg/kg: 2.8mg = 0.0028 * 500 = 1400 grams = 1.4 kg
Banerjee D1, Maity B, Nag SK, Bandyopadhyay SK, Chattopadhyay S., 31st January 2015, 'Healing potential of Picrorhiza kurroa (Scrofulariaceae) rhizomes against indomethacin-induced gastric ulceration: a mechanistic exploration.'. The BMC Complementary and Alternative Medicine Journal, Volume 8, issue 3, DOI: 10.1186/1472-6882-8-3.
Shen GF1, Guo W, Zhao WC., October 2012, '[Antiulcer effects and mechanism study of Veronicastrum axillare on ethanol induced gastric ulcer rats].' Zhongguo Zhong Xi Yi Jie He Za Zhi, volume 32, issue 10, pages 1370-3.
Babincová M1, Schronerová K, Sourivong P., December 2008, 'Antiulcer activity of water extract of Scoparia dulcis.' Fitoterapia., Volume 79, issues 1 - 2, pages 587 - 8. DOI: 10.1016/j.fitote.2008.05.001
Mesía-Vela S1, Bielavsky M, Torres LM, Freire SM, Lima-Landman MT, Souccar C, Lapa AJ., 4th May 2007, 'In vivo inhibition of gastric acid secretion by the aqueous extract of Scoparia dulcis L. in rodents.' J Ethnopharmacol, volume 111, issue 2, pages 403 - 8.
Aloe Vera:
https://www.ncbi.nlm.nih.gov/pubmed/27840496
https://www.ncbi.nlm.nih.gov/pubmed/24261674
https://www.ncbi.nlm.nih.gov/pubmed/28555939
https://www.ncbi.nlm.nih.gov/pubmed/27516663
Nexium - this is esomeprazole, refuted to be faster acting and a more efficient proton pump inhibitor than the typically used omeprazole. https://www.researchgate.net/public...ministration_of_Esomeprazole_Magnesium_Nexium
Lots of anecdotes re. nexium use here but take with a big pinch of salt.
https://www.chronofhorse.com/forum/...0-esomeprazole-nexium-for-equine-ulcers/page5
It's all meant to be done WITH Omeprazole treatment though, not instead of, and most of the studies were done in rodents as mice & rats genome is 95% identical to the human genome and other rodents (e.g. guinea pigs) have a very similar immune system. Plus they are cheaper and easier to keep than horses who are large, potentially dangerous, and expensive to keep in a lab setting.
Dosages were for my horse's estimated weight of 500kg. So adjust as necessary.
As always, polite correction re. the sciencey bits is welcomed.
Supplementing with Convolvulaceae family
Sweet potatoes - a member of the Convolvulaceae - has been found to have ulcer-reducing properties as they reduce the presence of free radicals and thereby reduce oxidative stress.
Equine dose is calculated off 200mg/kg dosage for rats: 200mg = 0.28 grams. 0.2 * 500 = 100
Motawi TK1, Hamed MA, Hashem RM, Shabana MH, Ahmed YR., January 2012, 'Protective and therapeutic effects of Argyreia speciosa against ethanol-induced gastric ulcer in rats.' Z Naturforsch C., volume 67, issue 1-2, pages 47 - 57.
Jaiswal SK1, Rao CV, Sharma B, Mishra P, Das S, Dubey MK., 1st September 2011, 'Gastroprotective effect of standardized leaf extract from Argyreia speciosa on experimental gastric ulcers in rats.' J Ethnopharmacol, Volume 137, issue 1, pages 141 - 4.
Awaad AS1, Al-Refaie A2, El-Meligy R3, Zain M4, Soliman H5, Marzoke MS6, El-Sayed N7., December 2016, 'Novel Compounds with new Anti-Ulcergenic Activity from Convolvulus pilosellifolius Using Bio-Guided Fractionation.' Phytother Res., volume 30, issue 12, pages 2060 - 64. DOI: 10.1002/ptr.5730.
Plaintain: (Ribwort and Broadleaf): 1.4 kg/day (pm)
These common members of the Plantaginacae family promote mucous production, thereby reducing acidity via dilution and neutralisation. They also contain compounds which promote tissue growth and repair - accelerating the healing process - and reduce oxidative stress, which is soothing.
Equine dosage was calculated off a rodent dose of 2.8mg/kg: 2.8mg = 0.0028 * 500 = 1400 grams = 1.4 kg
Banerjee D1, Maity B, Nag SK, Bandyopadhyay SK, Chattopadhyay S., 31st January 2015, 'Healing potential of Picrorhiza kurroa (Scrofulariaceae) rhizomes against indomethacin-induced gastric ulceration: a mechanistic exploration.'. The BMC Complementary and Alternative Medicine Journal, Volume 8, issue 3, DOI: 10.1186/1472-6882-8-3.
Shen GF1, Guo W, Zhao WC., October 2012, '[Antiulcer effects and mechanism study of Veronicastrum axillare on ethanol induced gastric ulcer rats].' Zhongguo Zhong Xi Yi Jie He Za Zhi, volume 32, issue 10, pages 1370-3.
Babincová M1, Schronerová K, Sourivong P., December 2008, 'Antiulcer activity of water extract of Scoparia dulcis.' Fitoterapia., Volume 79, issues 1 - 2, pages 587 - 8. DOI: 10.1016/j.fitote.2008.05.001
Mesía-Vela S1, Bielavsky M, Torres LM, Freire SM, Lima-Landman MT, Souccar C, Lapa AJ., 4th May 2007, 'In vivo inhibition of gastric acid secretion by the aqueous extract of Scoparia dulcis L. in rodents.' J Ethnopharmacol, volume 111, issue 2, pages 403 - 8.
Aloe Vera:
https://www.ncbi.nlm.nih.gov/pubmed/27840496
https://www.ncbi.nlm.nih.gov/pubmed/24261674
https://www.ncbi.nlm.nih.gov/pubmed/28555939
https://www.ncbi.nlm.nih.gov/pubmed/27516663
Nexium - this is esomeprazole, refuted to be faster acting and a more efficient proton pump inhibitor than the typically used omeprazole. https://www.researchgate.net/public...ministration_of_Esomeprazole_Magnesium_Nexium
Lots of anecdotes re. nexium use here but take with a big pinch of salt.
https://www.chronofhorse.com/forum/...0-esomeprazole-nexium-for-equine-ulcers/page5
