katef2020
Member
My 28 y/o welsh B, has been happily on pergolide for over 5 years and has had a symptom free happy time.
He was fit, ridden , doing PC and winning veteran classes until a few months ago, when he got mild laminitis following an episode of diarrhoea. He is already carefully monitored weight / dietwise and his insulin is always in normal range. He is slim and fed appropriately. He was in clogs within hours of laminitis attack and instantly much happier.
His ACTH has always been hugely high, was 600 when diagnosed with minimal symptoms 5 years ago, stabilised at 300 quite happily and then started to rise to 600 ( dose up to 2 mg/ day) then to over 1000 last year. He seems unable to tolerate more than 1mg every other day of pergolide now, is on protexin to try and stabilise things and this has worked with his tummy which is much better, and the lami seems under control, and he is cantering about in his clogs and much brighter.
Questions -
is the pergolide doing anything for him at all positive anymore?
He is an enigma with his huge levels of ACTH which he seems to tolerate well, will this go off the scale if I stop the pergolide alltogether ?
Is it basically everything else giving up, causing lack or tolerability of pergolide at therapeutic dose ?
Is pergolide excreted via liver - and could this mean he has some liver deficiency which is stopping him clearing it and causing toxicity ?
Any advice for this beyond pergolide scenario. I am pragmatic as to his options, but would like to give him every chance, without condemning him to his remaining time being full of unpleasantness.
He was fit, ridden , doing PC and winning veteran classes until a few months ago, when he got mild laminitis following an episode of diarrhoea. He is already carefully monitored weight / dietwise and his insulin is always in normal range. He is slim and fed appropriately. He was in clogs within hours of laminitis attack and instantly much happier.
His ACTH has always been hugely high, was 600 when diagnosed with minimal symptoms 5 years ago, stabilised at 300 quite happily and then started to rise to 600 ( dose up to 2 mg/ day) then to over 1000 last year. He seems unable to tolerate more than 1mg every other day of pergolide now, is on protexin to try and stabilise things and this has worked with his tummy which is much better, and the lami seems under control, and he is cantering about in his clogs and much brighter.
Questions -
is the pergolide doing anything for him at all positive anymore?
He is an enigma with his huge levels of ACTH which he seems to tolerate well, will this go off the scale if I stop the pergolide alltogether ?
Is it basically everything else giving up, causing lack or tolerability of pergolide at therapeutic dose ?
Is pergolide excreted via liver - and could this mean he has some liver deficiency which is stopping him clearing it and causing toxicity ?
Any advice for this beyond pergolide scenario. I am pragmatic as to his options, but would like to give him every chance, without condemning him to his remaining time being full of unpleasantness.
