Dales ponies: performance problems; blood tests; muscle enzymes

flintfootfilly

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Has anyone else had performance problems in their Dales ponies, combined with high muscle enzymes? Would really love to hear from anyone who has, as I try to figure out what’s going on with my gang.

Over the last few months, I’ve been looking into the cause of one of my Dales pony’s reluctance in his work (reluctant to trot, slow, stiff hind limb action, grinding to a halt, inconsistent carriage) and have had several blood tests done along the way, as well as a biopsy to check for signs of muscle disease such as EPSM/PSSM/RER etc.

I’ve also had all the ponies tested by hair sample for type 1 EPSM, and all came back negative for that. Only £25 per pony, so quick, easy and painfree to ponies and my wallet! So at least that ruled out one type of EPSM.

Anyway, last week I decided to have all my ponies (5 purebred Dales ponies and one partbred Dales) blood tested at least as a baseline for future reference, but also because I’ve had a nagging feeling about a few of them being not quite as consistent in their work as they might be.

The blood results have ALL come back with abnormal muscle enzyme levels (CK, AST and LDH), and I could have predicted those which would come back highest and lowest (because they tie in with the scale of reluctance to work): Max (the pony whose had most investigations) has CK levels 10X the “top normal” of 350; the rest of the gang range from marginally high to twice or three times top normal, and all are above the lab’s reference range for “normal”.

To have quite so many abnormally high muscle enzyme results is starting to sound a little more than coincidence to me. Common links are me, my land (although one pony has barely been on grass in the last 9 months), my hay/haylage (bought in from neighbouring land), the drinking water, the way I train them (minimal stress, gradually increasing work, and beside which one of them has been retired two years, and two are only just coming into work as youngster )......

Muscle enzymes from the most recent resting bloods came back as follows:
(“normal” reference range: AST 100-370; CK 20-225 (with “top normal” of 350 being recognised by experts such as Stephanie Valberg/Sue Dyson, Beth Valentine, Dr Kellon); LDH 130-1085

Max AST 526; CK 3,578; LDH 1,261
Megz AST 362; CK 542; LDH 964
Rose AST 609; CK 913; LDH 2,130
Fox AST 622; CK 493; LDH 1,140
Zebedee AST 405; CK 331; LDH 1,422
Rock AST 418; CK 562; LDH 1,697

I’m in touch with two American vets – Beth Valentine (who is an expert on EPSM in draft horses) and Dr Kellon (who runs a series of online courses for horse-owners and is someone who really hunts for an answer to veterinary problems), and they have both been incredibly helpful so far. My own vets are being as helpful as they can, but they are not familiar with this type of muscle problem. I’ve also been in touch with a couple of people from this board who have had ponies with muscle problems. It’s probably unlikely that I’ll get to the bottom of what’s happening with my gang, but I’m starting to wonder whether the muscle issues are environmental (ie related more to me and how I manage the ponies) or whether it is something which is found in other Dales ponies?

If anyone has experienced similar problems with their Dales pony, or had abnormally high muscle enzyme levels in their blood tests, then I’d really love to hear, either on here or by pm. Muscle enzyme levels and a brief outline of any problems you noticed with the pony’s performance would be really helpful.

I promise I will keep all details confidential, and will only use them to help in the management of my gang or to help experts find an answer.

Thank you!

Sarah
 
hm never heard of this before though the dale x pony I ride is incredibly workshy, fairly stiff in on of her back legs and lethargic/lazy ! I just put it down to her personality though that shes lazy and finds work like too much hard work! she has her moments however where shes quite fizzy but only really if shes wound up for whatever reason.

originally bred to drive at show-level but didn't have the stamina apparantly aka too lazy imo and been sold on as a happy hacker ever since.

I wouldn't know anything about "high muscle enzymes" though, so I wouldn't have any idea that anything might be contributing to her perceived lazy ways.

Interesting post though, I hope you find something to help your dales.
 
Hello,
I have a vague thing in the back of my head saying selenium deficiancy. I am in Dales pony area (County Durham) and the area I live in is known to be deficiant in Selenium, more evident because of problems in sheep. I just googled selnium deficiancy and it mentioned links with tying up which are (I think) associated with muscle enzymes.

I may be talkling absolute nonsense, anyone feel free to correct me! Might be worth a mention to vet? Or else a soil test in your grazing. Hay may be simular if grown in same area. However I would seek advice on supplementing if low as can cause problems in excess
 
My darty had slightly raised enzymes. Turns out it was tape worm infestation. Is it worth running a test to rule out?

Nikki
 
A very brief update.

I've been pursuing the possibility of it being selenium deficiency.

The two worst affected ponies were tested for whole blood glutathione peroxidase (GSH-px) and this came back in normal reference range. However, I'd read a paper by the late Helen Fullerton to parliament's Agriculture Committee and had seen in there that she had felt the current reference range was too low to pick up selenium-responsive conditions, so I decided to carry on pursuing selenium deficiency as a cause (given that other signs fitted with that).

After 4 weeks of high level selenium supplementation, Rose and Max's GSH-px levels have increased significantly .

Most importantly, I started to notice subtle improvements in their work tolerance around 3.5 weeks into supplementation. And now at nearly 6 weeks into supplementation, the improvements are clear.

Max and Rose have ridden out twice this week. Just a short walk-only 3 mile ride, but both were enthusiastic and striding out, with no grinding to a halt or any sign of reluctance. It may not sound much, but it is a dramatic improvement. There was no stopping as if wanting to pee or poo. Just walking out nicely.

Bloods are not yet showing any significant decrease in muscle enzymes, although I'm hopeful that we will see these on the next blood results, given how much more comfortable these two ponies especially seem.

So I'm pretty convinced it is selenium deficiency, and am quite encouraged to have so clear a response so soon.

At this rate, blood GSH-px should reach the lower level that I want to aim for (150U/ml PCV, based on work on livestock farm supplementation by a trace element company over 35 years) within about 5 months, which fits in well with the 5 month life cycle of red blood cells (in which most of the blood selenium is carried).

Will update when there's any more news, but I really do feel very encouraged at the moment.

Sarah
 
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