Dense question- bute vs danilon

[chaps89]

Ok, dense question coming up (count yourself warned)

What's the difference between bute and danilon?
Danilon seems to be more palatable (ie, mums mare who won't eat any food containing bute will eat same feed with danilon in), and from what I can tell is better for the horse long term due to less interference with liver/kidney functions?
But why and how are they different medicinally?

Cross posted in Vets too.

 

[Hippona]

Both anti-inflammatory....just some as you say are less aggressive on the renal and gastric system.

Its like with humans...there are several anti-inflammatory drugs.....some are better tolerated and some are more prone to causing side effects.

 

[kellyeaton]

there is no difference in pain killing and anti inflammtrie action it is just more platable and less harmful to the organs!

 

[chaps89]

But how is it less damaging to the internal organs? Without compromising the effect?

Thanks for answering so far tho

Not meaning to be a pain in the a$$, I thought of it earlier and it's bugging me now!

 

[Hippona]

You want pharmacology?

NSAIDS (non-steroidal anti-inflammatories) reduce the production of prostaglandins ( which cause pain during inflammation) by inhibiting the enzyme cyclo-oxygenase (COX)....different nsaids vary in their selectivity for inhibiting different type of COX so therefore some are better tolerated than others....prostaglandins give gastric protection so therefore if that is inhibited so isth egastric protection.

Phew...flashback. Learnt something at Uni then

 

[JanetGeorge]

Only 3 relevent differences between bute and Danilon.

1. Danilon is more palatable.
2. Danilon is kinder to the stomach (no difference in effect on kidneys, liver etc, if fed in large doses)
3. Danilon is more expensive.

 

[brucea]

And Danilone is converted in to the same as "bute" by he body - but after it gets past the stomach so better tollerated I understand. Same drug - just a different presentation.

 

[Doris68]

As Janet said - my old girl has been on Danilon (vet's advice...Rossdales!) for well over 3 years and has (hooves crossed) suffered no side-effects to date!

 

[chaps89]

[ QUOTE ]
You want pharmacology?

NSAIDS (non-steroidal anti-inflammatories) reduce the production of prostaglandins ( which cause pain during inflammation) by inhibiting the enzyme cyclo-oxygenase (COX)....different nsaids vary in their selectivity for inhibiting different type of COX so therefore some are better tolerated than others....prostaglandins give gastric protection so therefore if that is inhibited so isth egastric protection.

Phew...flashback. Learnt something at Uni then

[/ QUOTE ]

Well remembered. Yes, pharmacology helped, if only to get my head round it.

Thanks for the replies guys