Does pergolide work?

I have never used pergolide but have found Agnus Cactus (chaste berry) to be excellent
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Yes, in my experience. Personally, I would put a horse straight onto pergolide if it had Cushings but Vitex (Agnus Castus) can be useful in the early stages. It made huge differences within a couple of weeks with my mare.
 
The problem comes when people only give it for a few months and expect the horse to be 100% perfect again!!! it obviously doesnt work like that!

Alot of people use chastetree berry, but there is very little evidence (scientifically) to prove it works. However I know some people swear by it!

Other options, if pergolide doesnt work, are Cyproheptadine and trilostane.
 
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