Feeding Ertugliflozin

SEL

SEL

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It was chaotic at the vets when I picked up the Appy's drugs and there was no equine staff there I could double check anything with (& they're not the best during the week - too busy)

I've been given the pots of paste with the aim of syringing, but that's not going well

Can anyone who has fed these pots let me know dosage and approx weight of their horse? My Appy is 75% draft and a chunk even when she's fighting weight and I'm not sure they've got the dosage right

TIA
 
Best to double check with your vets as yes it goes on bodyweight but think it also depends how overweight (sorry) or how high the blood results are.

Is there not a prescription label on the pot for your horse? Dosage should be on there
 
HorsesRule2009 said:
Best to double check with your vets as yes it goes on bodyweight but think it also depends how overweight (sorry) or how high the blood results are.

Is there not a prescription label on the pot for your horse? Dosage should be on there
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Probably didn't make myself clear - yes they've put the dosage on the pot but it seems low for the size she is!

I'm trying to understand other people's dosages to see if it's been worked out correctly. Wouldn't be the first time vets have got their maths wrong.
 
I found this on a multiple vet sites

"Ertugliflozin falls into the sodium glucose co-transport-2 (SGLT2) inhibitors category and is administered orally at a dosage of 0.05 mg/kg once daily, for at least 30 days."

The label should tell you how many mg are in the stuff you've been given, either as weight in weight, w/w or weight in volume w/v.

ETA standard tube seems to be 5mg/ml, so for a 500 kg horse you would need 5 ml. (0.05mg x 500kg = 25mg, 5mg per mil, 25÷5 = 5.)

So it is a really small amount, it must be a pretty powerful drug!


Sorry if any of that is teaching you to suck eggs.
 
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ycbm said:
I found this on a multiple vet sites

"Ertugliflozin falls into the sodium glucose co-transport-2 (SGLT2) inhibitors category and is administered orally at a dosage of 0.05 mg/kg once daily, for at least 30 days."

The label should tell you how many mg are in the stuff you've been given, either as weight in weight, w/w or weight in volume w/v.

ETA standard tube seems to be 5mg/ml, so for a 500 kg horse you would need 5 ml. (0.05mg x 500kg = 25mg, 5mg per mil 25÷5 = 5)

So it is a really small amount, it must be a pretty powerful drug!


Sorry if any of that is teaching you to suck eggs.
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Actually that's perfect!

I landed on my head yesterday and can barely count my fingers this morning so multiplication isn't happening. She's on 6ml but she's never been under 620kg at her fittest (could feel ribs) so she's more 700kg currently. Her crest would look great on a stallion.

Given getting the stuff out of the pot is far from accurate (it's E45 cream texture and as much seems to end up on the outside of the syringe as in it) I'll just continue wiping the outside off on a treat to avoid wastage and then she's likely getting a bit more than 6ml

Thank you 🙂

(If ever there was a horse destined to send me to an early grave it's this one)
 
My friends mare is on this. 5ml per day, fed first thing in the morning, at the same time each day. When using the pots rather than the syringe, i use a 5ml teaspoon, spread it with some banana on a lick mat and made it far easier to feed.
 
ycbm said:
I hope it works!
.
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me too - its pricey and given she can't be ridden any more options are pretty limited if she won't stay the right side of the electric fencing :rolleyes:

KC31 said:
My friends mare is on this. 5ml per day, fed first thing in the morning, at the same time each day. When using the pots rather than the syringe, i use a 5ml teaspoon, spread it with some banana on a lick mat and made it far easier to feed.
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I didn't even think about using a teaspoon!! We have a whole measuring set of stuff for cooking purposes here that we never use and can repurpose. I'm sure I'm getting more of the stuff on the outside of the syringe than inside it.

maya2008 said:
Give in morning feed, once a day. Never had an issue with it being eaten.
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For a horse who usually guzzles anything in a bucket the smell of this seems to have really offended her. To me it smells of molasses but I'm having to sprinkle sainfoin over the top to avoid the bucket being tipped over in a huff.
 
SEL said:
Thank you.

Were you on the tubs? I think I'm going to try tablets next month
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Mine had one tablet per day, and was happy to take it from my hand with a few nuts , much less hassle than trying to syringe a paste in . If I have to syringe anything I mix with a little sugar free yoghurt
 
We had the 100ml tubs. So for us was 3 tubs over 2 months as an initial course.
Was molasses flavoured. As a fussy pony he had no issue with the paste, just with the syringe. Used a spoon after a couple of weeks and sort of smeared it on his tongue with no issues when it became routine.
SEL said:
Thank you.

Were you on the tubs? I think I'm going to try tablets next month
Click to expand...
 
Make sure she drinks plenty of fluid, for example by making sure it’s spotlessly clean, having a salt lick next to it and/or putting salt in feed, feeding sloppy mash etc. SGLT-2 inhibitors can cause UTIs in people at least because of the glucose excreted in the urine.
 
Both my ponies had a course of it last year - my 12hh Welsh was on 3ml per day and my 13hh chunky cob type was on 4ml per day. After around 6-8weeks they both were dropped down a ml (after new set of blood tests) then eventually stopped once insulin levels came back normal.

I had the 100ml tubs and bought syringes off Amazon which made getting it out the tub much easier. The best syringes I tried were ones with a metal/tube bit on the end, they were advertised as being used for arts & crafts for ink. I kept the pot in the fridge at home and just filled up the syringes to the correct doses and took them to the yard each morning 😊
 
My 12.2 300gk Dartmoor was on 3ml a day, but it was easier as it came in a calibrated syringe. Then we had to taper her off after a month or two.
 
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