Grey and melanomas study

FieldOrnaments

FieldOrnaments

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The reason for the association between grey and melanoma has been elucidated
Slow greying ponies aren't at elevated risk of melanoma as fast greying ones are

www.ncbi.nlm.nih.gov

White horses – non-coding sequences drive premature hair greying and predisposition to melanoma

The Grey allele in horses is causing premature hair greying and susceptibility to melanoma. The causal mutation is a 4.6 kb tandem duplication in intron 6 of the Syntaxin 17 gene. A recent study demonstrated that the most common allele at the Grey locus ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
 
I've been trying to find if there is any research into melanoma in grey allele horses that also carry two copies of cream and therefore do not have dark skin. Have seen melanoma at an early age with this and wondered if there was any real research been done.
 
Gloi said:
I've been trying to find if there is any research into melanoma in grey allele horses that also carry two copies of cream and therefore do not have dark skin. Have seen melanoma at an early age with this and wondered if there was any real research been done.
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afaik there's not been - only into the grey/melanoma link - although LP/TRPM1 is protective against melanoma
 
I saw one of these studies a while ago, very interesting to see a review thank you.
Screenshot_20241003-090937.pngScreenshot_20241003-091007.png
These bits I thought were very interesting however this explains more clearly than I've seen previously that g2 is a very rare phenomenon not just standard slightly slower greying that I previously assumed. Like this guy a connie with very slow greying, it's also seen in PREs. Screenshot_20240926-071045~2.png
 
This is really interesting, thank you for sharing :)

Recently I thought that there may have been something with greying and incidences of melanoma after a friends young grey(white) had to have a fair amount lasered off whilst my older slow greying pony hasn't got any so I'm glad I was actually thinking in the right direction!
 
Very interesting! My mare went grey (white) very young and has quite a lot of melanomas under her tail. Although she is 26 now and they haven’t grown in years (touch wood) and don’t bother her.
 
Thanks for posting this, I saw this the other day but didnt have time to read it, and then couldnt find it again.

Ive wondered for a while now, if breeding 2 greys would mean a higher incidence of melanoma in the resulting progeny . Hence why ive used non greys on my grey mare. Ive always assumed that grey sire and grey dam 2 copies of the grey gene = fast greying
But this year, one of my foals has greyed really quickly, but his dam isnt grey but sire is.
 
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Asha said:
Ive wondered for a while now, if breeding 2 greys would mean a higher incidence of melanoma in the resulting progeny . Hence why ive used non greys on my grey mare. Ive always assumed that grey sire and grey dam 2 copies of the grey gene = fast greying
But this year, one of my foals has greyed really quickly, but his dam isnt grey but sire is.
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I wondered this too, and I have heard some older breeders say not grey on grey, but they also say similar about bays🤔
Anyway my first 2 grey dales did not fully grey out til 11/12 years. I have a 4yr old grey filly (who is out of a grey and by a grey) who is following a similar time line comparing to old pics
But then I have a 2 yr old who is by a grey sire and a roan dam, and to my surprise he is greying out faster than the 4 yr old so who knows.
One of my mares , now 16yrs old has a small sarcoid under her tail

I have noticed that the grey ponies my neighbour breeds (Welsh b's) are mainly fully greyed out by 3/ 4 yrs, his stallions are currently chestnut and liver chestnut
 
tda said:
I wondered this too, and I have heard some older breeders say not grey on grey, but they also say similar about bays🤔
Anyway my first 2 grey dales did not fully grey out til 11/12 years. I have a 4yr old grey filly (who is out of a grey and by a grey) who is following a similar time line comparing to old pics
But then I have a 2 yr old who is by a grey sire and a roan dam, and to my surprise he is greying out faster than the 4 yr old so who knows.
One of my mares , now 16yrs old has a small sarcoid under her tail

I have noticed that the grey ponies my neighbour breeds (Welsh b's) are mainly fully greyed out by 3/ 4 yrs, his stallions are currently chestnut and liver chestnut
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thats really interesting. Ive never heard about not bay on bay.
Sarcoids is interesting too, as the ones ive had with them have been bay/black.
 
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Asha said:
thats really interesting. Ive never heard about not bay on bay.
Sarcoids is interesting too, as the ones ive had with them have been bay/black.
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I'm talking about native ponies specifically Dales
One of the worst affected by sarcoids ponies I've ever seen is a bay
 
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