Interesting research re Asthma (people and horses)

[palo1]

As I have a horse with allergic asthma I am interested to read around that and recently found some really interesting stuff about the gut biome and asthma. Experiments on mice, and supplementation for children of probiotics (including yeassac) have yielded some really positive results in reducing asthma severity, attacks and damage to the respiratory system. In horses the relationship between the respiratory system and gut biome is not yet well researched or understood but as yeassac is safe and the 'most effective' dose (established in mice) is within the normal equine supplementation levels, I have started using it. I may not notice any difference of course but it will be interesting to see and is, thankfully a safe, simple and relatively cheap experiment! Here are a couple of the research papers I found:-

Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models

One of the unmet needs for asthma management is a new therapeutic agent with both anti-inflammatory and anti-smooth muscle (ASM) remodeling effects. The mannose receptor (MR) family plays an important role in allergen uptake and processing of major allergens ...

www.ncbi.nlm.nih.gov

Probiotics in Children with Asthma

A type-2 immune response usually sustains wheezing and asthma in children. In addition, dysbiosis of digestive and respiratory tracts is detectable in patients with wheezing and asthma. Probiotics may rebalance immune response, repair dysbiosis, and mitigate ...

www.ncbi.nlm.nih.gov

If course, there are limitations to all of the research but as our knowledge of the gut biome and immune system develops, some of the propositions are interesting and make sense to me at least!

 

[MiJodsR2BlinkinTite]

This is interesting. Mine was diagnosed with Asthma.

Seems that gut biome is responsible for a helluva lot; I follow the "Zoe"/Dr Tim whatever-he-is page on FB and he says the same. Gut biome. My god how boring, but hey if this is what makes the universe go round then so be it, LOL.

 

[sbloom]

I love the factoid that the human gut has more brain cells than a cat has in its head and it does indeed seem that the quickest way to heal so many things is to heal the gut first.

 

[palo1]

I love the factoid that the human gut has more brain cells than a cat has in its head and it does indeed seem that the quickest way to heal so many things is to heal the gut first.

Yes, it is particularly interesting too in relation to soil health and wider food production and consumption; I am certain that the links between gut health and healthy microbial diversity will be increasingly important in how we see ourselves and our role in that area.

 

[palo1]

This is interesting. Mine was diagnosed with Asthma.

Seems that gut biome is responsible for a helluva lot; I follow the "Zoe"/Dr Tim whatever-he-is page on FB and he says the same. Gut biome. My god how boring, but hey if this is what makes the universe go round then so be it, LOL.

I wonder if the microbiome testing is helpful - do you have any experience of that? I think a central issue, for me with that is that we don't know enough about which bacteria are necessary or helpful yet (with horses) so it's hard to know how to develop a super healthy equine microbiome though I guess that knowledge is developing quite rapidly.

 

[palo1]

The Microbiota and Equine Asthma: An Integrative View of the Gut–Lung Axis

Ex vivo, mouse, and human studies have pointed to the gut microbiota as playing roles in many diseases, including asthma susceptibility and severity. Equine asthma shares many similarities with human asthma, and gut microbiota could also be critical components ...

www.ncbi.nlm.nih.gov

This is directly related to horses and is interesting but less direct in some ways to the others in terms of evidenced intervention.

this is interesting too : https://www.atsjournals.org/doi/10.1165/rcmb.2017-0228OC

 

[SEL]

I've got one with asthma and it seems to flare up on the grass which is interesting (it flared up when she moved to a new field in Dec, so not pollen). She head shakes horribly when it flares up too.

She's never had the best gut but I've had her 4 years now and we're no longer leaving huge stinky cow pats everywhere so hopefully that's a positive.

Spirulina and oily herbs at the moment but I did do a run last year of Immubiome's 'spine and nerve' which also helped and I know there's stuff in that which is supposed to help guts.

 

[palo1]

I've got one with asthma and it seems to flare up on the grass which is interesting (it flared up when she moved to a new field in Dec, so not pollen). She head shakes horribly when it flares up too.

She's never had the best gut but I've had her 4 years now and we're no longer leaving huge stinky cow pats everywhere so hopefully that's a positive.

Spirulina and oily herbs at the moment but I did do a run last year of Immubiome's 'spine and nerve' which also helped and I know there's stuff in that which is supposed to help guts.

Yes, it's just so tricky to know what is what. My mare, thankfully is symptom free over Autumn and winter and easy to support until about May when she might start needing steroids: On and off till late summer ( likely a grass pollen issue) I know I am lucky too but I wish I knew what actually helped, or not! I think a pollen mask does help, as does being high on a hill with short grass, being slim and fit and in spite of veterinary scepticism, anti-histamines. Yeassacc might help too I guess!