Is danilon really kinder than bute ?

Achinghips

Achinghips

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I read somewhere recently, can't remember where, that there really is no statistical research about danillon being kinder on the stomach than bute. It's just sweeter and more palatable. Furthermore, the makers of Danilon have had to withdraw any claims that it is ..... Can anyone verify this or point me in the direction of any empirical studies to the contrary please? (I have a lad on long term NSAIDs for arthritis, and nothing come close for his comfort, alongside his steroid injections).
 
That’s what my Vets told me when I was using it for both my old lads. When it breaks down to do its job, it’s no different to equapalazone.

The chemistry of the two are different though, so maybe it could be less harsh?
 
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My vets told me there is no difference between the two in terms of effect on stomach and other safety profile. Danilon is a bit more palatable and equally effective but the claims of kindness on the stomach are false.
 
Does the coating on Danilon make it easier on the stomach, its just that if you try to dissolve Danilon in liquid it just stays in granules but if you put bute in liquid it mixes in

My vet says its just easier on the stomach
 
Achinghips said:
I read somewhere recently, can't remember where, that there really is no statistical research about danillon being kinder on the stomach than bute. It's just sweeter and more palatable. Furthermore, the makers of Danilon have had to withdraw any claims that it is ..... Can anyone verify this or point me in the direction of any empirical studies to the contrary please? (I have a lad on long term NSAIDs for arthritis, and nothing come close for his comfort, alongside his steroid injections).
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My vets will always try and offer you Equipalazone unless you ask for Danilon, I was under the impression it was coated in something which protected the stomach from the effects of the drugs
 
I've never thought of it as kinder on the stomach but I always ask for it rather than bute as I have never had a problem with a horse eating danilon, whereas at least half of horses won't readily eat bute IME. Nothing worse than a horse in pain that refuses its meds!
 
cinnamontoast said:
They metabolise in exactly the same way so pretty similar. Dunno where the claims of being kinder on the stomach came from.
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I guess it's because one hits the stomach as bute, and the other doesn't become bute until it reaches the liver?

The research above supports the view that uncoated bute causes ulcers and danilon doesn't so much.
 
ycbm said:
I guess it's because one hits the stomach as bute, and the other doesn't become bute until it reaches the liver?

The research above supports the view that uncoated bute causes ulcers and danilon doesn't so much.
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That's certainly my understanding .
 
I guess that is why danilon has a do not use in animals with hepatic disorders attached to it. Not something I have given much thought to before and would hope the vet would know but I shall make a mental note anyway ;).
 
All drugs have the potential to screw up the liver, including Bute or Danilon, to me the liver is the most important part of the body, if the liver is not functioning correctly nothing else can

https://en.wikipedia.org/wiki/Phenylbutazone

I once drank something with bute in it, not on purpose I might add, it was a pretty awful experience, I doubt Danilon would of been any better except crunching the granules may of alerted me that all was not well :)

Hate to think where we would be without bute or danilon
 
The sugar coating only protects the stomach for the first couple of doses, as it is a physical barrier. As in humans, routine use of nsaid's over days or weeks results in a systemic response from the body - reduced production of gastric mucus, thinning of the gastric mucosa.
I cannot tolerate prolonged use of ibuprofen gel for this reason, a few days of it and my stomach gets irritated.
 
Cecile said:
I once drank something with bute in it, not on purpose I might add, it was a pretty awful experience, I doubt Danilon would of been any better except crunching the granules may of alerted me that all was not well :)
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I'm curious, how was the whole experience for you? :eek:
 
Nasicus said:
I'm curious, how was the whole experience for you? :eek:
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It made me light headed, not clear thinking, feeling quite sick and after a few hours the most awful banging headache, quite a few other things happened although fairly minor and by then I realised the error I had made so I was very focused on what was happening, I needed the loo quite often later...........

I am 5' tall and only weighed about 7 stone at that time, the drink was for a 16.2hh so I was probably slightly overdosed too
 
Cecile said:
It made me light headed, not clear thinking, feeling quite sick and after a few hours the most awful banging headache, quite a few other things happened although fairly minor and by then I realised the error I had made so I was very focused on what was happening, I needed the loo quite often later...........

I am 5' tall and only weighed about 7 stone at that time, the drink was for a 16.2hh so I was probably slightly overdosed too
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Blimey, that sounds awful! I am very curious to know how you ended up drinking the horses drink though! Was it hidden in a cuppa to disguise the taste or something?
 
Nasicus said:
Blimey, that sounds awful! I am very curious to know how you ended up drinking the horses drink though! Was it hidden in a cuppa to disguise the taste or something?
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It was completely my own fault, I made up a drink in a mug for the next feed, dashing around on a hot day, went into the tack room, the mug was there and downed it all except the bits in the bottom, the other mug was right next to it. You only ever make this mistake once, it was in apple juice
 
Cecile said:
All drugs have the potential to screw up the liver, including Bute or Danilon, to me the liver is the most important part of the body, if the liver is not functioning correctly nothing else can

https://en.wikipedia.org/wiki/Phenylbutazone

I once drank something with bute in it, not on purpose I might add, it was a pretty awful experience, I doubt Danilon would of been any better except crunching the granules may of alerted me that all was not well :)

Hate to think where we would be without bute or danilon
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Absolutely but when you have a horse which is suspected to have some degree of liver damage, but is of an age where sometimes pain relief is required as that takes precedent and if the liver crashes than so be it, the fact that one comes with an absolute do not use against it and one doesn't becomes rather important.
Because yes I have just had to have said horse on a weeks worth of bute, fingers crossed the issue seems to have resolved but if it is bute and eating, or no bute and not eating choices are somewhat limited.
 
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