Selenium deficiency

BBP

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I’ve done a search but can’t find the answers. Those who have had horses tested for selenium deficiency, what sort of results were you getting? How much below the reference range were they and what sort of effect was it having? Thank you.
 

quizzie

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I’ve done a search but can’t find the answers. Those who have had horses tested for selenium deficiency, what sort of results were you getting? How much below the reference range were they and what sort of effect was it having? Thank you.

Test for Selenium actually looks at the glutathione enzyme levels......My horse with selenium deficiency showed stiffness/reluctance/front limb lameness that didn't respond to nerve blocks.

GSH-Px was 22 ( Range 39-250)

As he has a yeast allergy, I had to source sodium selenite, and he now has a dose of 3mg,
5 days of the week (Mon-Fri) , which keeps his levels at around 180, which resolved his issues .

His Vitamin E levels were normal.
 

BBP

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Test for Selenium actually looks at the glutathione enzyme levels......My horse with selenium deficiency showed stiffness/reluctance/front limb lameness that didn't respond to nerve blocks.

GSH-Px was 22 ( Range 39-250)

As he has a yeast allergy, I had to source sodium selenite, and he now has a dose of 3mg,
5 days of the week (Mon-Fri) , which keeps his levels at around 180, which resolved his issues .

His Vitamin E levels were normal.

Thank you. Do you know what the units for your results were please?
 

BBP

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Sorry, thought I had included that!...U/ml

Tests performed by Axiom veterinary laboratories.
Thanks, so is that ug/ml? Either way looks like your horse was 50% ish under the low end of the reference range? I’m glad to hear the supplementation has helped.
 

quizzie

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Thanks, so is that ug/ml? Either way looks like your horse was 50% ish under the low end of the reference range? I’m glad to hear the supplementation has helped.

It isn't specified as ug so I assume it is Units per ml....Ideally they should be at least 100, and frequently do better nearer the top of the range, but obviously with care not to exceed!. When I gave him 3mg daily, the level crept up to 242, so just dropped a couple of days to give him a safety margin.
 

BBP

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My vets seem to use a completely different reference range so I’m assuming they are different units. Thanks for letting me know yours though.
 

quizzie

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My vets seem to use a completely different reference range so I’m assuming they are different units. Thanks for letting me know yours though.

It totally depends on which test which laboratory use...which isn't exactly helpful in comparative terms, but the specific range for the laboratory used is the important thing. The result needs to be in range, and I would suggest, that in the case of selenium, it should be in the upper region of the range.
 

BBP

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It totally depends on which test which laboratory use...which isn't exactly helpful in comparative terms, but the specific range for the laboratory used is the important thing. The result needs to be in range, and I would suggest, that in the case of selenium, it should be in the upper region of the range.
I haven’t got the result in writing yet (awaiting the vitamin E return) but vet told me they haven’t ever seen selenium so low except in extremely thin malnourished rescue cases that came in to the horse charity they worked for. He has historically been vitamin E deficient despite high levels of supplementation but it looks like his selenium has plummeted too. It’s a bit of a shock as selenium has always been fine.
 

quizzie

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I haven’t got the result in writing yet (awaiting the vitamin E return) but vet told me they haven’t ever seen selenium so low except in extremely thin malnourished rescue cases that came in to the horse charity they worked for. He has historically been vitamin E deficient despite high levels of supplementation but it looks like his selenium has plummeted too. It’s a bit of a shock as selenium has always been fine.
It may well be very relevant to BBPs issues, as although vit E/selenium work together, and it is sometimes assumed that they are interchangeable to some extent, they also work synergistically, and with some horses, it would appear that deficiency in one or the other seems to impair the function as a whole if that makes sense!

At one point, despite broadly similar diet/management, I had one horse with selenium deficiency, but normal Vit E ( he has a leaky gut/allergy issue which probably affects absorption), and another with Vit E deficiency and normal selenium ( he has a form of muscle myopathy and can only utilise the Nano E version!)...they are sent to try us!
 

BBP

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Definitely! One never ending puzzle. We are waiting for the vit E to interpret it properly, but I think I’ll get the rest blood tested too.
 

quizzie

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Good idea, my selenium deficient horse only became clinically obvious after I switched to a very local hay...I live in a low selenium area, so grazing and hay were both low.
 

BBP

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What made you test your horses selenium levels?
For me, my horse suffers chronic vitamin E deficiency, perhaps to the point of vitamin E deficiency myopathy. Sometimes he has trouble getting up from lying down and it seems to improve on very high vit E supplementation so we think his muscles are affected. And because vit E and selenium go hand in hand I often add it to his routine monitoring of vit e. To be honest I hadn’t planned to test it this time as it has been normal every time but the vet misunderstood and ran it anyway, and thank goodness they did as it is shockingly low.
 

quizzie

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What made you test your horses selenium levels?
Part of a comprehensive poor performance competition horse work-up that did not fit a specific pattern of lameness/illness..…simply something to rule in or out as a contributing factor.
 

quizzie

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For me, my horse suffers chronic vitamin E deficiency, perhaps to the point of vitamin E deficiency myopathy. Sometimes he has trouble getting up from lying down and it seems to improve on very high vit E supplementation so we think his muscles are affected. And because vit E and selenium go hand in hand I often add it to his routine monitoring of vit e. To be honest I hadn’t planned to test it this time as it has been normal every time but the vet misunderstood and ran it anyway, and thank goodness they did as it is shockingly low.
Just a thought BBP….I know that the vitamin E test is very labile, and if the sample has not been handled correctly, the result can be significantly affected….I don’t believe the same is true of the selenium test, but as your result is so out of the normal run of results, would it be worth your vet’s repeating it to check it is correct before supplementing?!
 

BBP

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Just a thought BBP….I know that the vitamin E test is very labile, and if the sample has not been handled correctly, the result can be significantly affected….I don’t believe the same is true of the selenium test, but as your result is so out of the normal run of results, would it be worth your vet’s repeating it to check it is correct before supplementing?!
I had the same thought.
 

Karenchol

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I’ve done a search but can’t find the answers. Those who have had horses tested for selenium deficiency, what sort of results were you getting? How much below the reference range were they and what sort of effect was it having? Thank you.
I notice that this is last years post, but I’ve just had the test on my two horses. They are both very low 40!!! I have tested my mare for everything. Never did a vet suggest this as a possible issue. I’m pretty annoyed about it, as I’ve spent a fortune trying to work out what is wrong. It’s been a long 7yrs since I backed her. When my youngster also started with muscular symptoms I had to look again. He reacted differently to her, but basically both had muscle weakness/soreness. Resulting in bad behaviour in her and nappy behaviour in him. She got so bad I stopped riding her. It made her so anxious about everything it was dangerous. When he started not going forward off the leg I knew I had to look at something different. I’d tested my ground previously. No one mentioned selenium? This time I went for a blood test and specifically asked for it. This was also after chatting to local people about the ground locally. I just hope now I can correct any damage done to them.
 

Landcruiser

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This was my girl's results, as you can see the units and range are different. About half what it should be, with CK elevated (which was the blood result that led me to testing for selenium)
Request Date: 24/05/2023 SN11 8SD
Test Results
Name Result Units Interval
(SELEN) Selenium 697 nmol/L (ref range: 1200 - 3200)
(MUSCL) Muscle profile
AST 291 u/l@37C 62 - 579
CK H 621 U/l@37C 0 - 520

Then a month or so later, after supplements. Different reference range, CK and Sel both WNL:
___________________________________________________________________________

Request Date: 12/07/2023 SN11 8SD
Test Results
Name Result Units Interval
(ECK) CK
CK 492 U/l@37C 0 - 520
(EGSH) GSH-Px (selenium)
GSH-Px 183 U/ml R 39 - 250

And the next set this time clearly just over the range)
___________________________________________________________________________

Request Date: 16/08/2023 SN11 8SD
Test Results
Name Result Units Interval
(EGSH) GSH-Px (selenium)
GSH-Px H 267 U/ml R 39 - 250
 

Landcruiser

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How is your mare now, did she change with the correction?
Mine has slightly raised CK too.
Recent blood test (10/24) showed selenium bang in the middle of the reference range. She was much improved in movement and general demeanour within a couple of weeks of starting supplementing the Selenium last yr. I pay great attention to making sure her balancer has the correct amount because so many just don't contain enough.

Unfortunately she's now diagnosed as having EMS - she's a veritable "Whack a Mole" of symptoms and injuries (she's only 5).
 

Karenchol

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Recent blood test (10/24) showed selenium bang in the middle of the reference range. She was much improved in movement and general demeanour within a couple of weeks of starting supplementing the Selenium last yr. I pay great attention to making sure her balancer has the correct amount because so many just don't contain enough.

Unfortunately she's now diagnosed as having EMS - she's a veritable "Whack a Mole" of symptoms and injuries (she's only 5).
I’m so sorry your mare has other issues. I’ve been trying to find reasons my mare is like she is for 7 years. When my young gelding started having issues (different, but I think selenium issues. Muscle problems and reluctance to go forward) I asked for the specific blood test. I have now enlisted the help of a Nutritionlist to try and correct this. I really hope it is the answer to my problems with them.
 

Landcruiser

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I’m so sorry your mare has other issues. I’ve been trying to find reasons my mare is like she is for 7 years. When my young gelding started having issues (different, but I think selenium issues. Muscle problems and reluctance to go forward) I asked for the specific blood test. I have now enlisted the help of a Nutritionlist to try and correct this. I really hope it is the answer to my problems with them.
I supplemented with Trinity Consultants "Alpha Selenium" when she was deficient and now use Progressive Earth "Pro Laminae" as a daily balancer. This gives 1mg/day and along with her forage seems about right
 
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