Too much Prascend?

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DonskiWA

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My boy was started on Prascend approx. 3 months ago. He came good quite quickly on one tablet /day (introduced gradually). Over the least 3 weeks though, the top line has fallen off him and he's lost at least 50kgs (originally 520kg). His coat is dull and rough. He is only 15 but looks 35.

I have a vet appt. next week, but am just searching for answers in the meantime.
Someone suggested that is what can happen when their dose is too high? I can't imagine his cushings getting worse in only 3 months?

His ATCH at diagnosis was 65.
 
can you provide a bit more info? what he is eating, and supplements, is he on grass and for how long, when was he last wormed/counted?

Mine looked dreadful at 14 when first diagnosed, improved rapidly to a point but it took other things as well to get to where I am now. He is 18 and looks 8. I learnt along the way that ACTH tests do not give very accurate results! Cushings horses can have poor immune systems so if the vet is coming anyway you could do a general blood test to rule out anything else.
 
I'm in Australia actually, so the info I give you may not make much sense re: brands of foods etc. He's on a ton of sups including chaste berry. It's winter here of course, and he's out 24/7 (as most horses here are).
He is due for a worm though, so I might get onto that.
 
During winter here, it's the peak for cushings, and usually it's recommends to upp the dosage by half or quarter of a tablet, bringing it back down come Feb/March when comi back into spring, chaste berry will not help, prascend is the only thing that's proven to help symptoms of cushings, plus low sugar/starch diet ( less than 10% combined).
 
Tiddlypom said:
I don't think that you should give both prascend and chaste berry together? Could be wrong, but I'm sure I've read that.
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I have also read this somewhere, also agnus castus has been tested and found to not be effective.... as cushings is a progressive condition prascend only helps with the symptoms and doesn't cure the problem.
 
Worth a retest I'd think. My horse was diagnosed with levels only slightly above normal at end of Autumn (but with severe weight loss and muscle wastage and lethargy) and they improved initially on 1/2 tablet a day to high end of normal range a month into treatment. We retested around March time and he had levels of over 400 at a time when most people seem to find they can reduce the dose but we ended up increasing it again. A month after that we were down to about 70 and we're retesting again next month. At the time his levels with stupidly high he was showing no clinical signs. He did have some odd behaviour when dose was initially increased but they seem to have settled down again
 
'There is evidence in other species that a low dose of Vitex could inhibit dopamine, which is the opposite of the effect wanted for horses with PPID.

Wikipedia: Vitex agnus castus is assumed to have dopaminergic effects resulting in changes in prolactin secretion. At low doses Vitex agnus castus inhibits activation of dopamine 2 receptors by competitive binding, causing a slight increase in release of prolactin. At higher concentrations the binding activity is sufficient to reduce the release of prolactin.'

http://www.thelaminitissite.org/u-v-w-x-y-z.html
 
The mane thing would be high fibre low sugar/starch diet with some micronized linseed if you can get it over there not sure what it would be called
 
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