Worming - sorry!

We have used Equimax on our pregnant mares and foals spring and autumn as part of our worming program devised by Intellegent Worming which we used for over 24 months and HAD serious problems last autumn caused by ascarid resistance to ivermectin.

The problem with using Equimax / ivermectin + praziquantel as treatment for tape in young stock in the autumn as an alternative to double dosing with a pyrantel based product is that ivermectin resistant ascarids (roundworm) are on the increase. Many breeders use ivermectin throughout the grazing period and studies indicate that regular use of Ivermectin in foals during the grazing period is developing resistance. - The praziquantel contained in Equimax will assist with controling tape worm without further complications but roundworm may not be dealt with efficiently leaving foals and young animals open to further infestation and possible risk. This is much less of a problem in horses over two years of age as they tend to develop natural resistance to roundworm as they approach maturity.

http://www.parasitesandvectors.com/content/2/S2/S8

Equimax doesn't treat for encysted worm either and strongyles have known resistance to Pyrantel :rolleyes: (so what do we do now?) Ideally the optimal solution is therefore be to treat with a pyrantel based wormer at double the dose for tape which will also assist with removing ascarid resistant worms, followed by a treatment of either panacur five day guard or equest four to six weeks later to assist with eliminating pyrantel resistant strongyles and any encysted worms. This combination of treatments covers all species and any resistant strains. There is yet no single wormer that treats for everything so at least two different chemicals have to be used at interval.

Concerningly Ascarid Resistance has also now been established to Moxidectin (Equest) in foals and youngstock and it has also been noted in recent studies that Equest does not always cover a 13 week period in animals younger than two years of age, with clinical studies revealing the period of protection reduced to eight weeks.

Hadn't thought about it immogen but the latter may well be due to the fact that they have a lower mass of fat.

It might also be important to bare in mind that the reason equest is efficient at removing encysted worms is its ability to penetrate tissue and reach its target. The fact that it is stored enhances it's efficiency at controlling different larval stage development.

In the defense of Equest for the treatment of encysted worms in foals over six months of age.

http://www.parasitesandvectors.com/content/2/S2/S1

"In a recent study "The effects of removal of luminal stages of parasites on emergence of inhibited stages, whether by anthelmintic treatment or natural expulsion, must also be taken into account when designing new approaches to cyathostomin control programmes [76]. Another factor of importance to clinicians is the consequence of killing the inhibited stages, as it has been reported that the die-off of these stages following fenbendazole treatment results in severe inflammation of the mucosa of the colon. In the same study, inflammation was not seen subsequent to the elimination of these stages using moxidectin"

So whilst overdosing with equest does carry great risk prescribing the correct doseage also has it's advantages. - I guess it's up to the person administering the treatment to assure that the correct dose is given and weigh up the disadvantages of choosing an alternative which may also carry it's own consequences

http://www.parasitesandvectors.com/content/2/S2/S1

Personally I think that with the introduction of equimax primarily an ivermectin based wormer many horse owners have stopped double dosing spring and autumn with a pyrantel based wormer and think this has assisted with the development of resistance in the round worm population.

Bring back good old rotation!
 
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